Nicholas Kristof grew up, in rural Yamhill, Oregon, an area that prospered for much of the twentieth century but has been devastated in the last few decades as blue-collar jobs disappeared. About one-quarter of the children on Kristof's old school bus died in adulthood from drugs, alcohol, suicide, or reckless accidents. And while these particular stories unfolded in one corner of the country, they are representative of many places the authors write about, ranging from the Dakotas and Oklahoma to New York and Virginia. But here too are stories about resurgence, among them: Annette Dove, who has devoted her life to helping the teenagers of Pine Bluff, Arkansas, as they navigate the chaotic reality of growing up poor; Daniel McDowell, of Baltimore, whose tale of opioid addiction and recovery suggests that there are viable ways to solve our nation's drug epidemic. These accounts provide a picture of working-class families needlessly but profoundly damaged as a result of decades of policy mistakes.